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Although there is no definitive evidence regarding the causal relationship between the use of GLP-1 RAs in humans and the development of psychiatric AEs, the fact that psychiatric AEs have occurred after the use of GLP-1 RAs suggests that these reports warrant increased clinical attention, early detection, and intervention

The result: a plasma half-life of approximately 7 days

On the other hand, loop and thiazide/thiazide like diuretics, when used without a RAAS antagonist, do not protect glomeruli from the increased pression and hyperfiltration (41)