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Understanding which alterations are potentially serious helps patients distinguish between expected side effects and warning signs of complications

The SELECT trial showed that semaglutide reduced major adverse cardiovascular events (heart attack, stroke, cardiovascular death) in adults with obesity and established cardiovascular disease, without requiring a diabetes diagnosis. The FLOW trial showed kidney benefits with semaglutide use in patients with type 2 diabetes and chronic kidney disease. Improvements in hard clinical outcomes like cardiac events, kidney disease, and death are commonly observed with GLP-1 use, and are due to both the direct effects of treating the obesity, and indirect effects of the medications themselves

doi: 10.3389/fendo.2018.00672 (7) Zhao X, et al

Heres how the leading medications compare: Tirzepatide (Zepbound) and Liraglutide (Saxenda) are FDA-approved for chronic weight management