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It should also be noted that during our study period, semaglutide was reported to exhibit both the highest weight-reducing effect [5, 18] and reduction of glycemia [6], which could be a contributory factor to the increase in the use of this substance in particular

Synedica Retatrutide is suitable for adults with a BMI of 30 or above, or a BMI of 27 or above with at least one weight-related health condition such as high blood pressure, elevated cholesterol, or type 2 diabetes

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Common side effects include nausea, vomiting, diarrhea, and constipation, particularly during dose titration

But from a neuropathology perspective, the evidence is thin