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This occurs due to both reduced endogenous synthesis by the kidneys and the significant removal of this small, water-soluble molecule through the dialysis membrane

Medication BPC 157 (10 g/kg, 10 ng/kg) was applied either intraperitoneally once time daily (first application immediately after surgery, last at 24 hours before sacrifice) or per-orally in drinking water (0.16 g/ml/12 ml/day till the sacrifice) while controls simultaneously received an equivolume of saline (5 ml/kg) intraperitoneally or drinking water only (12 ml/day)

The medication should be discontinued at least two months before a planned pregnancy, as stated in the product information

you destroy a stable chemical bond to create an unstable chemical bond

Mechanisms Methods 30 (6), 397406