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The Km value of Na + -dependent GAA uptake by TR-CSFB cells (929 M) is comparable with that of GAA uptake by CRT-expressing HEK293 cells (412 M)/ Xenopus laevis oocytes (269 M), as well as that of TauT-expressing Xenopus laevis oocytes (215 M) [50, 56]

2026;9:e2553323

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The protective effect may be achieved either by directly neutralizing the ROS/RNS/other free radical species by the transfer of hydrogen atom and sequential proton loss electron transfer, maintaining the cellular redox balance, thereby protecting the cellular milieu from oxidative impairment, or upregulating the expression of cellular defensive genes or regulating various antioxidant signaling pathways