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Science 351 , 4348 (2016)

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Glutathione peroxidase 8 suppression by histone deacetylase inhibitors enhances endoplasmic reticulum stress and cell death by oxidative stress in hepatocellular carcinoma cells

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for patients experiencing: Pernicious anemia, with or without nervous system involvement Dietary B12 deficiency, including strict vegetarians and vegans Malabsorption of B12 due to stomach or intestinal issues affecting intrinsic factor General B12 deficiency symptoms, such as fatigue or neurological changes Administration Dosing depends on the severity of the patients deficiency and their clinical response