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Ethics declarations Ethics approval and consent to participate All animal experiments were conducted after approval from the Institutional Animal Care and Use Committee of the Tongji Medical College, Huazhong University of Science and Technology, and all procedures were in compliance with the relevant guidelines and regulations of the Chinese Council on Animal Care

Additionally, tirzepatide led to greater weight reduction than semaglutide

Many of the developmental observations were made decades ago, but their full importance can only now be understood after the realization in the living rodent and human brain of the huge glutamineglutamate (GABA) cycle flux determined in the brain in vivo and described below

If you are coming from tirzepatide, our guide on retatrutide dosing after tirzepatide addresses the specific considerations for that transition