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Dose-finding studies for CNS effects in humans are needed because extrapolation from rat doses is unreliable

Hormonal fluctuations, particularly during pregnancy or when taking oral contraceptives, can trigger melasma, a type of hyperpigmentation characterized by symmetrical brown patches typically appearing on the face

Symptoms of appendicitis include sharp abdominal pain starting around the navel and moving to the lower right abdomen, fever, nausea, vomiting, loss of appetite, and abdominal swelling

When youre constipated, your bowel movements could become stuck in the diverticula, and some experts believe that this issue could lead to the inflammation and infection that causes diverticulitis

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