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Human Data: While animal studies (mostly in rats) are overwhelmingly positive, large-scale, peer-reviewed human clinical trials are still limited

doi: 10.1016/j.bbrc.2017.10.077 130 YangW

The short-term side effects were localized pain, burning, prickling sensation (paresthesia), hearing changes, altered levels of blood thyroid-stimulating hormone and lactate, and hypomania (a mild form of mania)

With the increased emotional and physical stress, it is believed that the majority of the population has a degree of mitochondrial impairment that causes a cascading effect of inflammation and disease development

Moreover, the discovery challenges traditional views of CysLT-mediated inflammation and may help explain the effectiveness of current therapies that target these pathways