glp 1 effect on heart GLP-1 Agonists in Cardiovascular Diseases: Mechanisms, Clinical Evidence, and Emerging Therapies Impact of GLP-1 receptor agonists

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Such a condition is centered on the removal of inhibition of the carnitine handling enzyme CPT1 via the specific down-regulation of acetyl-CoA carboxylase 2 (ACC2), with a strong reduction of the malonyl-CoA pool responsible for CPT1 inhibition (Koundouros and Poulogiannis, 2020)

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Lipo C accelerates hepatic fat export through methyl donor pathways (methionine, choline) and intracellular fat transport (inositol), while GLP-1 agonists maintain the caloric deficit that allows that mobilized fat to be oxidized rather than re-stored