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In individuals with acquired hyperinsulinemic hypoglycemia after gastrointestinal surgery, including Nissen fundoplication and gastric bypass surgery, the incretin response to a meal is markedly increased and antagonism of the GLP-1 receptor prevents the hyperinsulinemic response

however, this was for diabetes indications and GLP-1s were not included on the EML for obesity

Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets