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Figure 1 Evidence-based effects of key nutrients After understanding the pathological connection between nutrients and OA and discovering the significant role of the metabolism-inflammation-oxidative stress network in it, this study explores key nutrients that can prevent or treat OA through evidence-based medicine and reveals the mechanisms by which they exert preventive or therapeutic effects (Table 1)

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256,257 Additionally, alanyl-tRNA synthetase 2 (AARS2) has been shown to act as a mitochondrial lactyltransferase as well, catalyzing the lactylation of K336 in pyruvate dehydrogenase complex 1 (PDHA1) and K457/8 in carnitine palmitoyltransferase 2 (CPT2) under hypoxic conditions

Household air pollution causes dose-dependent inflammation and altered phagocytosis in human macrophages