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1 Notably, not all patients respond optimally, indicating that other mechanisms are involved in vascular changes in DR

Anti-Inflammatory Effects: Systemic inflammation reduction by decreasing pro-inflammatory cytokines like TNF- 3/ Possible Chronic Disease Risk Reduction Cardiovascular Health: semaglutide a GLP-1-RA has shown promise of lifespan extension in obese individuals by reducing the risk of cardiovascular disease

Understanding this interaction matters when planning how to combine these approaches, when to start each one, and what to expect during the transition periods

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