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GLP-1 receptor agonists stimulate insulin secretion and may alter gallbladder function, potentially increasing acute pancreatitis risk in susceptible individuals

In the rabbit, higher doses of empagliflozin resulted in maternal and fetal toxicity at 700 mg/kg/day, or 139-times the 25 mg maximum clinical dose

Generic metformin, also used to treat diabetes, is associated with utilization management tools in only 30% of ACA Marketplace plans, almost exclusively in the form of quantity limits

doi: 10.1016/S2213-8587(23)00235-8

Beyond glycaemic control, they slash cardiovascular risk by up to 26%, reduce the progression of kidney disease, and treat fatty liver and sleep apnoea, among others