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(2005) did replicate many of the pathologic changes initially described by Schuknecht (1962), specifically loss of hair cells and supporting cells of the organ of Corti with variable degradation of the tectorial membrane, stria vascularis, spiral limbus, and cochlear neurons [71, 72]
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The mPFC and striatal neurons in the mesocorticolimbic system involve in reward-based associative learning as the blockade of both D1R and D2R in the monkeys PFC results in learning deficits [49, 50]
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As a Nrf2 activator, urolithin A not only protects kidney against oxidative stress via promoting Nrf2 translocating into nucleus (Zhang et al., 2022c), but also ameliorates hyperuricemic nephropathy via enhancing PINK1-associated mitophagy in renal TECs (Zhang et al., 2022a)
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