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Semaglutide roughly doubles the weight loss percentage of phentermine (13.7% versus 5-10%) over a much longer treatment duration

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The same authors indicate changes in the lipid metabolism-related genes (HSL, PPAR , and SIRT1) expression in LRD-fed mice, indicating an accelerated fat turnover (128)

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Here, we review therapies that combine GLP-1R pharmacotherapeutics with other weight loss mechanisms, which result in superior effects on body weight reduction and glucose metabolism

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