foxo4-dri senolytic 2023 2024 study peptide mouse Molecular modelling of the FOXO4-TP53 interaction to design peptides for the elimination of senescent cancer cells FOXO4-DRI Senolytic Peptide FOXO4-DRI Selectively Removes

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At the high doses found in illegal supplements there are concerns about liver toxicity and connections to cancer

Nutrients 12:305 Aktas O, Prozorovski T, Smorodchenko A, Savaskan NE, Lauster R, Kloetzel P-M, Infante-Duarte C, Brocke S, Zipp F (2004) Green tea epigallocatechin-3-gallate mediates T cellular NF-B inhibition and exerts neuroprotection in autoimmune encephalomyelitis

In preclinical models, reducing senescent cells has been associated with improved physical function and tissue homeostasis