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Given the lack of approved therapies targeting myelin maintenance or regeneration, it is imperative to understand the mechanisms by which microglia support and restore myelin health to identify potential therapeutic approaches

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However, nitrate/nitrite demonstrated a moderate effect size ( r = 0.35) for increase from pre (139.50 18.35 molL -1 6 hr -1 ) to post (172.40 21.75 molL -1 6 hr -1 ) intervention with ALCA, and the magnitude of decrease following feeding was not as pronounced as with placebo