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Description

Tirzepatide (Mounjaro, Zepbound) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (Mounjaro) and chronic weight management (Zepbound)

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Furthermore, mitochondrial GPX4 (GPX4 mito ) cooperates with the dihydroorotate dehydrogenase/CoQ 10 H 2 pathway and the glycerol-3-phosphate dehydrogenase 2 (GPD2)/CoQ 10 H 2 pathway on the inner mitochondrial membrane to inhibit ferroptosis [56, 57] (Fig

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