This is especially true if you are new to the medication, experiencing unusual symptoms, or have any underlying health conditions that might require specific guidance
Safety Profiles Side by Side Gastrointestinal Adverse Events | Event | Tirzepatide 15 mg (SURMOUNT-1) | Retatrutide 12 mg (Phase 2) | |---|---|---| | Nausea | 31% | 47% | | Vomiting | 16% | 25% | | Diarrhea | 22% | 17% | | Constipation | 19% | 13% | | Discontinuation due to GI AEs | 4.3% | 16.6% | Discontinuation rates in the retatrutide phase 2 trial were substantially higher than those seen in tirzepatide's phase 3 program, which may reflect a steeper titration schedule, the additional glucagon receptor burden, or the smaller trial population amplifying extreme responders [2][3]
Incretin Monoagonists Exenatide, based on exendin-4, was the first incretin agonist to receive Food and Drug Administration (FDA) approval in the USA, with diabetes indication in 2005
Review the dose chart if you need to adjust your schedule
1 In 2021, the Centers for Disease Control and Prevention (CDC) estimated about 9.6 million people across the United States had been diagnosed with diabetic retinopathy, of which 1.84 million have vision-threatening DR
