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In this article, we aim to provide a comprehensive overview of FES, with a focused review on the three most representative and critical forms of this condition

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Normal cells, which do not rely on FOXO4-p53 binding for survival, are unaffected

Notably, TGF- is considered the master regulator of fibrosis, and its downstream signalling is transduced primarily through the phosphorylation and activation of receptor-associated Smads (R-Smads), Smad2 and Smad3