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Furthermore, the demonstration of cardiovascular benefits across a broad range of adiposity levels, coupled with independence from weight loss magnitude, suggests that semaglutide and perhaps other GLP-1 receptor agonists should be reconceptualized as cardiovascular disease-modifying agents rather than solely medications for glycemic control or weight loss

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Since the unavailability of crystal structures of OATPs and relative difficulties in validating their homology models, pharmacophore models have helped elucidate the key molecular features involved in the substrate/inhibitor and protein interactions

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20 demonstrated, while some patients may require long-term therapy at the full dose for weight maintenance, others can taper their dose to a reduced maintenance level, and some may be able to discontinue therapy entirely whilst maintaining their desired weight