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However, if the pain persists or worsens beyond a week, it may indicate a more serious issue

Several molecular mechanisms have been identified that may explain resistance and increased invasion after anti-angiogenic therapy in glioma, including mesenchymal transition of tumor cells, up-regulation of pro-angiogenic factors, activation of MET and up-regulation of MMPs [293,294,295,296]

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Preclinical research has explored its interaction with cellular signaling pathways involved in vascular and inflammatory responses