(PubMed) Rader JI
PMID: 30281517 7 Primary and maternal 3-methylcrotonyl-CoA carboxylase deficiency: insights from the Israel newborn screening program
Notes: Acute tolerance (a reduction in response for a given dose) develops rapidly (less than 1 hour), but not at the same rate for different physiologic effects (skin temperature, heart rate, subjective effects) Withdrawal symptoms such as cigarette craving can be reduced in most individuals by plasma nicotine levels lower than those from smoking Withdrawal from nicotine in addicted individuals can be characterized by craving, nervousness, restlessness, irritability, mood lability, anxiety, drowsiness, sleep disturbances, impaired concentration, increased appetite, minor somatic complaints (headache, myalgia, constipation, fatigue), and weight gain References: Belkoniene M et al (2019): Near fatal intoxication by nicotine and propylene glycol injection: a case report of an e-liquid poisoning
Both alcohol and amitriptyline compete for the livers attention, but it can only do so much at a time
Common side effects: nausea, diarrhea, and constipation, especially during dose escalation