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195 Several systematic reviews or meta-analyses have attempted to comprehensively summarize the clinical data of GLP-1 RA in the treatment of AD or PD, but the results are still inconclusive, 196200 possibly because some clinical studies are still ongoing and require ongoing attention

Most patients (93%) tolerate side effects well enough to continue treatment

NICE also supports the use of licensed pharmacological treatments in eligible patients: Orlistat (available as a 60 mg over-the-counter preparation or 120 mg on prescription) is indicated alongside a calorie-controlled diet for adults meeting defined BMI thresholds

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they only tested mitofusin-2 levels, an indicator for mitochondrial activity, which was unaltered 259