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DHA not only reduces GSH to GSSG but also inactivates GPX4 directly, facilitating LPO accumulation and cell ferroptosis collaboratively (Figure 5E)
What makes these numbers particularly significant for women over 40 is the comparison to baseline expectations
I chose to write publicly about it for exactly this reason
SGLT2-i Initiation and Insulin De-Escalation In a retrospective cohort study by Champion et al., initiation of SGLT2-ioften in combination with metformin and/or a GLP-1 receptor agonistled to significant reductions in both insulin dose and overbasalization rates
27 It can be achieved via chronic energy restriction, the most extreme form of which is short-term starvation (STS, corresponding to water-only fasting) or intermittend fasting (IF) regimes such as only eating every other day
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