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Semaglutide is the active ingredient in diabetes drugs Ozempic, Rybelsus and Wegovy, a heart disease prevention and weight-loss drug

It is a synthetic fragment of human growth hormone (amino acids 176-191), studied in research settings for its proposed role in fat metabolism

Notably, at higher doses, weight loss appeared to be continuing at week 48 without a clear plateau

This 0.23% annual rate for type 2 diabetes patients is slightly lower than the overall pancreatitis rates mentioned earlier in this article (0.32-0.39%) from the broader clinical trial population, suggesting that having type 2 diabetes doesnt appear to significantly increase your pancreatitis risk with Mounjaro

Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of gamma-aminobutyric acid type A receptor alpha1 subunit knockout mice