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Lancet 389:528537 Weinblatt ME, Coblyn JS, Fox DA, Fraser PA, Holdsworth DE, Glass DN, Trentham DE (1985) Efficacy of low-dose methotrexate in rheumatoid arthritis

Blood, 112 (6), 22142221

115, pp

The dose is 100200 mg IM, 23 times weekly

Once in tissue fluid, copper ions detach briefly, triggering pathways that: Increase growth factors: Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) rise within hours, improving blood supply