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Eight in ten patients on the drug hit the clinical responder threshold of at least a 5% BMI reduction

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We do not know how much of it is absorbed through the skin, but generally, barring a few chemicals such as hydroquinone, absorption from intact skin is minimal

For diabetes management, HbA1c reductions typically range from 5-15 mmol/mol (0.5-1.5%) depending on the specific medication and dose, though targets should be individualised based on your circumstances as per NICE guidance