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The combination of cetuximab and -elemene not only promotes ferroptosis in CRC cells, but also promotes the expression of E-cadherin (epithelial marker) while reducing the expression of mesenchymal markers such as snail, vimentin, N-cadherin, slug, and MMP-9

Potential side effects, including nausea and concerns regarding long-term safety, remain under investigation

In contrast to cutaneous melanomas, which are etiologically linked to sun exposure, risk factors for mucosal melanomas are unknown

Intestinal enzymes break down the glutathione tripeptide before it crosses the intestinal barrier, limiting the amount reaching systemic circulation and target tissues

The GGT problem: Gamma-glutamyltransferase (GGT) is an enzyme concentrated in the intestinal brush border that cleaves the gamma-glutamyl bond in glutathione