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Specifically, retatrutide simultaneously activates three distinct hormone receptors: GLP-1 (glucagon-like peptide-1) receptors promoting insulin secretion, reducing appetite, and slowing gastric emptying GIP (glucose-dependent insulinotropic polypeptide) receptors enhancing insulin response and supporting fat metabolism Glucagon receptors increasing energy expenditure and promoting hepatic fat breakdown It is important to note that glucagon receptor activation can, in isolation, raise blood glucose levels