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By dosage, the mean changes were: 500 mcg: 127% 750 mcg: 176% (single study) 1,000 mcg: 280% 1,500 mcg: 310% 2000 mcg: 260% 5,000 mcg: 62% While 1,500 mcg of vitamin B12 showed the highest average increase, the effect plateaued or declined at higher doses, suggesting a possible saturation of absorption pathways

Similarly, hamsters immunized with recombinant SARS-CoV S protein trimer developed neutralizing antibodies and were protected against challenge 119

The expression of HDAC11 is decreased but the PAI-1 (a key pathophysiological regulatory factor, involved in processes including inflammation, fibrosis and apoptosis) expression is increased in the ischemia/reperfusion (I/R)-induced AKI male mice model and LPS-treated macrophages

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