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As such, including an additional outcome with less clinically meaningful threshold would overload the study results with redundant information rather than providing added clinical insights

Methods Patients and study design The study protocol was conducted in accordance with the guidelines contained within the Declaration of Helsinki and was approved by the ethics committees of Yokohama City University and Kyoto Prefectural University of Medicine

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Vitamin C (ascorbic acid) is a water-soluble nutrient with several recognised functions, including contributing to the protection of cells from oxidative stress