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The importance of mitochondrial glutathione extends to neurological health, as neurons are particularly vulnerable to oxidative damage due to their high metabolic demand and limited regenerative capacity

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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations HTLV-I: human T-cell leukemia virus type I ATL: adult T-cell leukemia TBP-2: thioredoxin-binding protein-2 VDUP1: vitamin D 3 upregulated protein-1 ASK1: apoptosis signal-regulating kinase 1 ROS: reactive oxygen species TMX: transmembrane thioredoxin-related protein ER: endoplasmic reticulum GSH: glutathione TRX: thioredoxin AIF: apoptosis-inducing factor IAPs: inhibitor of apoptosis proteins TRXR: thioredoxin reductase IL-2: interleukin-2 IL-2R : chain of IL-2 receptor HIV: human immunodeficiency virus AIDS: acquired immune deficiency syndrome ANT: adenine nucleotide translocator References Holmgren A and Bjrnstedt M (1995) Thioredoxin and thioredoxin reductase