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Unlike native IGF-1, this analog features a 13-amino acid N-terminal extension and an arginine substitution at position 3, conferring reduced affinity for insulin-like growth factor binding proteins (IGFBPs) and thus increased biological activity across multiple experimental models

[DOI] [PubMed] [Google Scholar] 13.Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH

5-Amino-1MQ (5-amino-1-methylquinolinium) is a selective inhibitor of NNMT nicotinamide N-methyltransferase