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discovered that the administration of Ginkgo biloba polysaccharides (GBP, 300 mg/kg) for consecutive 28 days effectively mitigated the antidepressant effects induced by chronic stress in mice, while also exerting antidepressant effects through rectifying dysregulated gut homeostasis, elevating brain levels of 5-HT and DA, and enhancing the abundance of Lactobacillus in the intestine ( Cistanche polysaccharides effectively mitigated the inflammatory response in the colon and ameliorated gut barrier disruption by modulating the dysbiosis of gut microbiota in rats subjected to chronic unpredictable stress, indicating that the antidepressant effect of Cistanche polysaccharides is also associated with their regulation on gut microbiota ( Polygonum sibiricum exhibited the ability to suppress depression-like behavior in perimenopausal mice induced by ovariectomy plus chronic mild stress (Zhang et al., 2022)

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