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FDA Mounjaro FDA Prescribing Information sNDA 215866s031, section 6.2 (Postmarketing), Feb 2025

GSH is known to modulate DNA synthesis by maintaining reduced glutaredoxin or thioredoxin, which are required for the activity of ribonucleotide reductase, the rate-limiting enzyme in DNA synthesis (Holmgren, 1981)

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[0038] Add 2-aminoisobutyric acid (1.24g, 12.0mmol), triethylamine (1.21g, 12.0mmol), chloroform (20mL) into the reaction flask, lower to 0C, add the above compound III (4.32g, 10.0 mmol) was incubated for reaction, and after TLC detected that the reaction was complete, water (20 mL) was added to the reaction system and stirred for 10 minutes, the organic phase was collected, and concentrated under reduced pressure until no liquid flowed out

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