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Thus, genetically determined increased MD-2 level (rs11465996) and TNFRSF1A (TNFR1) expression (rs4149570) and genetically determined decreased TNFAIP3 (A20) expression (rs6927172), IL-1 (rs3804099 and rs4848306), IL-6 (rs3804099 and rs10499563), IL-17 (rs2275913) and IFN- (rs2430561) levels were associated with beneficial response among patients with IBD