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CYP3A4 mediated N-demethylation to norhydrocodone is the primary metabolic pathway of hydrocodone with a lower contribution from CYP2D6 mediated O-demethylation to hydromorphone

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The short duration requires consistent daily dosing, but most patients adapt quickly to the routine

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Sleep improvements are typically the first thing patients at our Miami clinic report, often beginning within the first few nights of the cycle