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If prescribed, domperidone should only be used at the lowest effective dose for up to 7 days due to cardiac risks (QT prolongation), and is contraindicated in patients with certain cardiac conditions or taking interacting medications

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In vivo assays confirmed that BRWD3 binds cry in a light-dependent manner and, as a part of the BRWD3-Cullin4-RING Finger E3 Ligase (CRL4) complex, catalyzes cry ubiquitination and subsequent proteasomal degradation (Ozturk et al., 2013)