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Alternatively, efficacy may be lower than in Phase 2 (which sometimes happens when moving to larger populations) and Tirzepatide would remain the leading published comparator

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Unanswered Questions Regarding Weight Loss Mechanisms: Perspectives to Preclinical Research The exact mechanisms underlying the weight loss are still not clear, especially in light of the enhanced effects seen with multi-agonism, despite the large number of incretin agonists presently undergoing clinical trials and their remarkable effectiveness in managing obesity and T2DM [5, 14, 146, 147]

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