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2018 Oct [cited 2025 Jun 16];6(4):54857

If you develop yellowing of the skin or eyes (jaundice), dark urine, pale stools, severe abdominal pain, or persistent itching, stop taking berberine immediately and seek medical advice

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Adjust upward when you sweat, exercise, are in heat, or have vomiting or diarrhea

A settlement in the IPR context typically involves the challenger withdrawing its petition in exchange for some commercial concession from the patent holder, such as a licensing agreement, a supply agreement, or a negotiated market entry date