HUVECs grown in the 3D model exhibited not only a markedly elevated level of oxidative stress, expressed by an increased level of malondialdehyde and superoxide dismutase activity inhibition, but also an increased inflammatory response with more secretion of IL-1 and IL-6 in response to TNF- when compared to ECs grown on 2D TCPs
Hogan C, Serpente N, Cogram P, Hosking CR, Bialucha CU, Feller SM, Braga VM, Birchmeier W, Fujita Y (2004) Rap1 regulates the formation of E-cadherin-based cell-cell contacts
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They might suggest referral to an endocrinologist for comprehensive metabolic assessment, or to a specialist weight management service if obesity is a significant concern
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