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Specifically, certain miRNAs can target and regulate iron metabolism-related proteins or directly inhibit the expression of System Xc and GPX4, thereby promoting ferroptosis (Fan et al., 2021

GCL is a heterodimeric enzyme composed of a glutamate-cysteine ligase catalytic subunit (GCLC), which confers enzymatic activity, and a glutamate-cysteine ligase modifier subunit (GCLM), which enhances GCLC efficiency and attenuates feedback inhibition by GSH

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Performance on the Wisconsin card-sorting test and serum levels of glial cell line-derived neurotrophic factor in patients with major depressive disorder