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Conclusion Our systematic review, analyzing data from IF studies in different populations, suggests that IF could have immunomodulatory effects in healthy people, obese people, and people with special physiological and pathophysiological conditions

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Moreover, recent studies show that increased NF-B expression may be associated with central fatigue by modulating central nervous system genes and regulating immune-inflammatory processes, synaptic plasticity, and memory and exerting neurotoxic effects (3537)

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