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However, in preliminary studies we have found that BDHI 18 can inhibit surface expression of activation markers (CD25 and CD69) and reduce cytokine secretion (IFN-, IL-2, and IL-6) from primary human T-cells while maintaining cell viability (Figure S10), suggesting the cell permeability of this electrophile

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Oxidation of vitamin C to DHA by tumor stroma has been suggested 9 , complicating the ability to predict tumor responsiveness to the treatment

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MTHFR variants can reduce methylfolate production, which affects the methylation cycle and SAMe availability