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Process intensification can help, but experience so far suggests that the efficiency gains flatten sooner than in typical smallmolecule chemistry

no human clinical trials have been reported

Part D plans often make other changes from one year to the next that could affect drug coverage and costs, including changes to formularies and preferred pharmacies, re-enforcing the value for Part D enrollees in comparing plans during the annual open enrollment period

A drug with $2 billion in annual revenue and a single, broad CoM patent expiring in four years is a fundamentally different asset than one with the same revenue protected by a deep secondary thicket extending twelve years

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