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As the essential eNOS cofactor tetrahydrobiopterin (BH 4 ) is susceptible for oxidation, a landmark study by David Harrison's group 62 was able to proof the concept that superoxide produced by the Nox may indeed trigger eNOS uncoupling in the experimental animal model of DOCA-salt hypertension

However, the phytochemical composition of the extracts varies in function of the plant species, extraction methods and growth conditions, affecting reproducibility

10.1371/journal.pone.0007153 PLoS One 85 HjaL.NyitraiG.KkesiO.DobolyiSzabP.FithR.et al (2012)

[1] Signs and symptoms [edit] Hiatal hernia has often been called the "great mimic" because its symptoms can resemble many disorders

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