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They emphasized that HO-1 functions as an oxidative agonist rather than a driver of ferroptosis, and that ferroptosis occurs only as a secondary event following severe oxidative damage (155)

Insulin metabolism in polycystic ovary syndrome: secretion, signaling, and clearance

For example, rapid improvements in blood glucose control can cause temporary dizziness as your body adjusts to new metabolic conditions

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Animal experiments also provide strong evidence that the ovarian phenotype, including reduced ovulation rate and a dramatic decline in fertility, observed in hyh mutant (Napahyh/hyh) mice is based on an increased rate of apoptosis in GCs and follicular atresia (Arcos et al., 2017)