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These kinases phosphorylate the membrane transporters (DAT, NET, SERT), leading to two outcomes: the transporters are either internalized into the cell (ceasing all reuptake function) or they undergo a conformational shift that causes them to operate in reverse

Potential Side Effects and Risks: While generally safe, ESIs can have side effects, including temporary post-injection soreness, dizziness, headaches, and a temporary increase in blood pressure or blood sugar for diabetic patients

Pooyandjoo, M., et al

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Antibacterial SAR must therefore integrate permeability and efflux considerations from the earliest stages of design